F. Ivy Carroll, PhD, Distinguished Fellow in medicinal chemistry, appointed August 2002, joined RTI in 1960. He served as director of the Center for Organic and Medicinal Chemistry (1975-2007) and research vice president of the Chemistry and Life Sciences Group (1996-2001). Dr. Carroll has made major scientific contributions in drug discovery and development and other research areas. Among his most recognized scientific contributions is the development of a diagnostic agent for Parkinson's disease and compounds as potential treatments for cocaine and nicotine addictions and other central nervous system disorders. He also led and opioid project and designed solution-phase libraries in search of novel kappa opioid receptor antagonists. Further explorations led to his discovery of a super potent and selective kappa opioid receptor antagonist, named JDTic, which has subsequently been entered into clinical tests in humans.
He has published more than 481 peer-reviewed publications, 34 book chapters, 43 patents, and has more than 20 current patent applications. Dr. Carroll has received numerous awards for his research accomplishments. These include the 1993 Pacesetter Award, National Institute on Drug Abuse; the 1993 Distinguished Speaker Award, North Carolina Section of American Chemical Society; the 2000 Southern Chemist Award, Memphis Section of American Chemical Society; the 2001 Charles H. Herty Medal, Georgia Section of American Chemical Society; the 2001 Margaret E. Knox Excellence Award, Research Triangle Institute; the 2002 Division of Medicinal Chemistry Award, American Chemical Society; the 2006 Nathan B. Eddy Award from the College on Problems of Drug Dependence; and the 2006 Research Achievement Award in Drug Design and Discovery from the American Association of Pharmaceutical Scientists.
He also received the 2010 North Carolina Award for Science; the 2010 National Institute on Drug Abuse Public Service Award for Significant Achievement; the 2012 GlaxoSmithKline Alfred Burger Award in Medicinal Chemistry from the American Chemical Society; the 2012 International Narcotics Research Conference Founder’s Lecturer Award; and the 2012 Auburn University College of Science and Mathematics Distinguished Alumnus Award.
In 2007, he was inducted into the American Chemical Society Medicinal Chemistry Hall of Fame.