Non-toxic camptothecin prodrugs are prepared by esterifying the20-position hydroxyl group of camptothecin derivatives.
Water-soluble esters of camptothecin compounds
Wall, M., & Wani, M. (2000). IPC No. U.S. Water-soluble esters of camptothecin compounds. (U.S. Patent No. 6040313). http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=6040313
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