RTI uses cookies to offer you the best experience online. By clicking “accept” on this website, you opt in and you agree to the use of cookies. If you would like to know more about how RTI uses cookies and how to manage them please view our Privacy Policy here. You can “opt out” or change your mind by visiting: http://optout.aboutads.info/. Click “accept” to agree.
In utero exposure to bisphenols and asthma, wheeze, and lung function in school-age children
A prospective meta-analysis of 8 European birth cohorts
Abellan, A., Mensink-Bout, S. M., Garcia-Esteban, R., Beneito, A., Chatzi, L., Duarte-Salles, T., Fernandez, M. F., Garcia-Aymerich, J., Granum, B., Iñiguez, C., Jaddoe, V. W. V., Kannan, K., Lertxundi, A., Lopez-Espinosa, M.-J., Philippat, C., Sakhi, A. K., Santos, S., Siroux, V., Sunyer, J., ... Casas, M. (2022). In utero exposure to bisphenols and asthma, wheeze, and lung function in school-age children: A prospective meta-analysis of 8 European birth cohorts. Environment international, 162, Article 107178. https://doi.org/10.1016/j.envint.2022.107178
BACKGROUND: In utero exposure to bisphenols, widely used in consumer products, may alter lung development and increase the risk of respiratory morbidity in the offspring. However, evidence is scarce and mostly focused on bisphenol A (BPA) only.
OBJECTIVE: To examine the associations of in utero exposure to BPA, bisphenol F (BPF), and bisphenol S (BPS) with asthma, wheeze, and lung function in school-age children, and whether these associations differ by sex.
METHODS: We included 3,007 mother-child pairs from eight European birth cohorts. Bisphenol concentrations were determined in maternal urine samples collected during pregnancy (1999-2010). Between 7 and 11 years of age, current asthma and wheeze were assessed from questionnaires and lung function by spirometry. Wheezing patterns were constructed from questionnaires from early to mid-childhood. We performed adjusted random-effects meta-analysis on individual participant data.
RESULTS: Exposure to BPA was prevalent with 90% of maternal samples containing concentrations above detection limits. BPF and BPS were found in 27% and 49% of samples. In utero exposure to BPA was associated with higher odds of current asthma (OR = 1.13, 95% CI = 1.01, 1.27) and wheeze (OR = 1.14, 95% CI = 1.01, 1.30) (p-interaction sex = 0.01) among girls, but not with wheezing patterns nor lung function neither in overall nor among boys. We observed inconsistent associations of BPF and BPS with the respiratory outcomes assessed in overall and sex-stratified analyses.
CONCLUSION: This study suggests that in utero BPA exposure may be associated with higher odds of asthma and wheeze among school-age girls.
RTI shares its evidence-based research - through peer-reviewed publications and media - to ensure that it is accessible for others to build on, in line with our mission and scientific standards.