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Human rights of people living with HIV (PLHIV) and key populations most affected by HIV are often violated, with negative implications for health outcomes. To facilitate access to justice in Ghana, a consortium of partners developed a web-based discrimination reporting system. The reporting system links the Commission on Human Rights and Administrative Justice (CHRAJ) to civil society organizations through case reporting, follow-up, and aggregated reported data use. A reporting system can form a critical part of a country’s human rights protection network. In Ghana, the combination of a supportive legal framework, an institutional home, and engaged stakeholders have created a favorable environment for developing such a system. Other institutions may learn from Ghana’s experience by adapting these lessons.