• Journal Article

A translational behavioral model of mood-based impulsivity: Implications for substance abuse

Citation

Gipson, C. D., Beckmann, J. S., Adams, Z. W., Marusich, J., Nesland, T. O., Yates, J. R., ... Bardo, M. T. (2012). A translational behavioral model of mood-based impulsivity: Implications for substance abuse. Drug and Alcohol Dependence, 122(1-2), 93-99. DOI: 10.1016/j.drugalcdep.2011.09.014

Abstract

Background: Laboratory tasks that measure various facets of impulsivity derived from self-report questionnaires are important for elucidating the behavioral consequences of impulsivity in humans and for back-translating these facets to non-human species. Negative urgency, or mood-based rash action, is a self-report facet of impulsivity linked to problem substance use; however, a valid behavioral task is lacking. Methods: The current studies were designed to bridge self-report questionnaire and behavioral measures of negative urgency in humans and to determine if this could be back-translated to rats. Results: Humans scoring high in negative urgency showed greater behavioral responding and increased frustration following unexpected reward omission on a monetary-based task compared to subjects low in negative urgency. Rats also showed elevated responding for either sucrose pellets or intravenous amphetamine following unexpected reward omission. Conclusion: These results suggest that impulsive behavior engendered by unexpected reward omission may represent a valid behavioral model of negative urgency linked to substance abuse. (C) 2011 Elsevier Ireland Ltd. All rights reserved