• Article

Thielavin B methyl ester: a cytotoxic benzoate trimer from an unidentified fungus (MSX 55526) from the Order Sordariales

As part of our ongoing investigation of filamentous fungi for anticancer leads, an active fungal extract was identified from the Mycosynthetix library (MSX 55526; from the Order Sordariales). Bioactivity-directed fractionation yielded the known ergosterol peroxide (2) and 5 alpha,8 alpha-epidioxyergosta-6,9(11),22-trien-3 beta-ol (3), and a new benzoate trimer, termed thielavin B methyl ester (1). The structure elucidation of 1 was facilitated by the use of HRMS coupled to an APPI (atmospheric pressure photoionization) source. Compound 1 proved to be moderately active against a panel of three cancer cell lines. (C) 2011 Elsevier Ltd. All rights reserved

Citation

Ayers, S., Ehrmann, B. M., Adcock, A., Kroll, D. J., Wani, M., Pearce, C. J., & Oberlies, N. H. (2011). Thielavin B methyl ester: a cytotoxic benzoate trimer from an unidentified fungus (MSX 55526) from the Order Sordariales. Tetrahedron Letters, 52(44), 5733-5735.