Thielavin B methyl ester: a cytotoxic benzoate trimer from an unidentified fungus (MSX 55526) from the Order Sordariales
Ayers, S., Ehrmann, B. M., Adcock, A., Kroll, D. J., Wani, M., Pearce, C. J., & Oberlies, N. H. (2011). Thielavin B methyl ester: a cytotoxic benzoate trimer from an unidentified fungus (MSX 55526) from the Order Sordariales. Tetrahedron Letters, 52(44), 5733-5735.
As part of our ongoing investigation of filamentous fungi for anticancer leads, an active fungal extract was identified from the Mycosynthetix library (MSX 55526; from the Order Sordariales). Bioactivity-directed fractionation yielded the known ergosterol peroxide (2) and 5 alpha,8 alpha-epidioxyergosta-6,9(11),22-trien-3 beta-ol (3), and a new benzoate trimer, termed thielavin B methyl ester (1). The structure elucidation of 1 was facilitated by the use of HRMS coupled to an APPI (atmospheric pressure photoionization) source. Compound 1 proved to be moderately active against a panel of three cancer cell lines. (C) 2011 Elsevier Ltd. All rights reserved