Targeting RNA with cysteine-constrained peptides
Burns, V. A., Bobay, B. G., Basso, A., Cavanagh, J., & Melander, C. (2008). Targeting RNA with cysteine-constrained peptides. Bioorganic and Medicinal Chemistry Letters, 18(2), 565-567. DOI: 10.1016/j.bmcl.2007.11.096
A combined approach for targeting RNA with novel, biologically active ligands has been developed using a cyclic peptide library and in silico modeling. This approach has successfully identified novel cyclic peptide constructs that can target bTAR RNA. Subsequently, RNA/peptide interactions were effectively modeled using the HADDOCK docking program. (c) 2007 Elsevier Ltd. All rights reserved.