3 alpha-(Substituted phenyl)nortropane-2 beta-carboxylic acid methyl esters (8a-h) showed high affinity for the norepinephrine transporter (NET). The most potent and selective compound was 3 alpha-(3-fluoro-4-methylphenyl)nortropane-2 beta-carboxylic acid methyl ester (8d), with a K-i of 0.43 nM at the NET and 21- and 55-fold selectivity relative to binding at the dopamine and serotonin transporters. The development of 8d makes available compounds selective for all three transporters from the same structural class
Synthesis and monoamine transporter binding properties of 3 alpha-(substituted phenyl)nortropane-2 beta-carboxylic acid methyl esters. Norepinephrine transporter selective compounds
Carroll, F., Tyagi, S., Blough, B., Kuhar, MJ., & Navarro, H. (2005). Synthesis and monoamine transporter binding properties of 3 alpha-(substituted phenyl)nortropane-2 beta-carboxylic acid methyl esters. Norepinephrine transporter selective compounds. Journal of Medicinal Chemistry, 48(11), 3852-3857.
Abstract
Publications Info
To contact an RTI author, request a report, or for additional information about publications by our experts, send us your request.
Meet the Experts
View All ExpertsRecent Publications
Article
Multifaceted risk for non-suicidal self-injury only versus suicide attempt in a population-based cohort of adults
Article
Community overdose surveillance
Article
Epigenetic biomarkers for smoking cessation
Article