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Sleep and fatigue symptoms in children and adolescents with CKD
A cross-sectional analysis from the Chronic Kidney Disease in Children (CKiD) Study
Roumelioti, M. E., Wentz, A., Schneider, M. F., Gerson, A. C., Hooper, S., Benfield, M., Warady, B. A., Furth, S. L., & Unruh, M. L. (2010). Sleep and fatigue symptoms in children and adolescents with CKD: A cross-sectional analysis from the Chronic Kidney Disease in Children (CKiD) Study. American Journal of Kidney Diseases, 55(2), 269-280. https://doi.org/10.1053/j.ajkd.2009.09.021
Background: Although symptoms of sleepiness and fatigue are common in adults with chronic kidney disease (CKD), little is known about the prevalence of these symptoms in children with CKD. Study Design: Cross-sectional analysis within a cohort study. Setting & Participants: We describe the frequency and severity of sleep problems and fatigue and assess the extent of their association with measured glomerular filtration rate (mGFR) and health-related quality of life (HRQOL) in 301 participants of the Chronic Kidney Disease in Children cohort. Outcomes & Measurements: Sleep and fatigue-related items from the Pediatric Quality of Life Inventory 4.0 Generic Scales and the CKD-related Symptoms List were used. Results: Median mGFR was 42.0 mL/min/1.73 m2 (25th-75th percentiles, 31.2-53.2), and median age was 13.9 years (25th-75th percentiles, 10.8-16.2). Children with mGFR of 40-