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Serum matrilysin levels predict outcome in curatively resected colorectal cancer patients
Martinez-Fernandez, A., Garcia-Albeniz, X., Pineda, E., Visa, L., Gallego, R., Codony-Servat, J., Auge, J. M., Longaron, R., Gascon, P., Lacy, A., Castells, A., & Maurel, J. (2009). Serum matrilysin levels predict outcome in curatively resected colorectal cancer patients. Annals of Surgical Oncology, 16(5), 1412-1420. https://doi.org/10.1245/s10434-009-0405-9
Matrix metalloproteinase 7 (MMP-7) is involved in invasion, metastasis, growth, and angiogenesis. The aim of this study is to assess the prognostic role of serum MMP-7 in curatively resected colorectal cancer (CRC).
Patients undergoing resection for CRC (n = 175) were recruited from July 2003 to December 2004. MMP-7 was determined using a quantitative solid phase sandwich ELISA. Cox analysis was used to assess the role of MMP-7 in predicting overall survival (OS) and disease-free survival (DFS).
The median length of follow-up was 45 months (range 1 to 59). Levels of MMP-7 are predictors of DFS (hazard ratio [HR] 1.119, 95% confidence interval [95% CI] 1.038-1.207) and of OS (HR 1.113, 95% CI 1.025-1.209). Patients with MMP-7 higher than the median (4.3 ng/ml) are more likely to relapse (29.5% vs 18.4%, P = .084); median time to progression in relapsed patients is 8 months if MMP-7 is a parts per thousand yen4.3 ng/ml and 18 months if MMP-7 is <4.3 ng/ml. Node-negative patients with low MMP-7 have a predicted probability of relapse-free survival at 4 years of 88% (95% CI 83-92%); if the MMP-7 is higher than the median value; this probability is 77% (95% CI 73-81%).
MMP-7 predicts recurrence in curatively resected CRC patients.