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Sensitivity improvement in isotropic mixing (TOCSY) experiments

Cavanagh, J., & Rance, M. (1990). Sensitivity improvement in isotropic mixing (TOCSY) experiments. Journal of Magnetic Resonance (1969), 88(1), 72-85. https://doi.org/10.1016/0022-2364(90)90109-M

Abstract

A simple modification of the two-dimensional TOCSY experiment which leads to a √2 improvement in sensitivity is described. This improvement is achieved by retaining the magnetization transfer pathways from both of the orthogonal, in-phase magnetization components which are present during the isotropic mixing period. In addition, a simple baseline correction procedure which can greatly improve the quality of NMR spectra is described.

10.1016/0022-2364(90)90109-M

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