Sensitivity improvement in isotropic mixing (TOCSY) experiments
A simple modification of the two-dimensional TOCSY experiment which leads to a √2 improvement in sensitivity is described. This improvement is achieved by retaining the magnetization transfer pathways from both of the orthogonal, in-phase magnetization components which are present during the isotropic mixing period. In addition, a simple baseline correction procedure which can greatly improve the quality of NMR spectra is described.
Cavanagh, J., & Rance, M. (1990). Sensitivity improvement in isotropic mixing (TOCSY) experiments. Journal of Magnetic Resonance (1969), 88(1), 72-85. DOI: 10.1016/0022-2364(90)90109-M