• Article

In search of synergy strategies for combining interventions at multiple levels

The social ecological perspective provides a compelling justification for multilevel intervention. Yet, it offers little guidance for selecting interventions that work together in complementary or synergistic ways. Using a causal modeling framework, we describe five strategies for increasing potential complementarity or synergy among interventions that operate at different levels of influence: accumulation, amplification, facilitation, cascade, and convergence. We illustrate these strategies with examples of multilevel interventions to improve the quality of cancer treatment.


Weiner, B., Lewis, M., Clausner, S., & Stitzenberg, K. (2012). In search of synergy: strategies for combining interventions at multiple levels. Journal of the National Cancer Institute Monographs, (44), 34-41. https://doi.org/10.1093/jncimonographs/lgs001