• Journal Article

Safety and pharmacokinetics of multiple dose myo-inositol in preterm infants

Citation

Phelps, D. L., Ward, R. M., Williams, R., Nolen, T., Watterberg, K. L., Oh, W., ... Higgins, R. D. (2016). Safety and pharmacokinetics of multiple dose myo-inositol in preterm infants. Pediatric Research, 80(2). DOI: 10.1038/pr.2016.97

Abstract

BACKGROUND: Preterm infants with respiratory distress syndrome (RDS) given inositol had reduced bronchopulmonary dysplasia (BPD), death and severe retinopathy of prematurity (ROP). We assessed the safety and pharmacokinetics of daily inositol to select a dose providing serum levels previously associated with benefit, and to learn if accumulation occurred when administered throughout the normal period of retinal vascularization. METHODS: Infants