Risk of cardiovascular, gastrointestinal, and renal adverse events associated with diclofenac immediate and extended release drug products

An observational study using US claims data

Mladsi, D., Goyal, R., Cryer, B., Hopkins, WE., Brater, CD., Korsnes, J., Candrilli, S., Castellsague, J., & Varas-Lorenzo, C. (2015). Risk of cardiovascular, gastrointestinal, and renal adverse events associated with diclofenac immediate and extended release drug products: An observational study using US claims data. Value in Health, 18(3), A292. https://doi.org/10.1016/j.jval.2015.03.1701

Abstract

Safety studies have shown that risks associated with use of non-steroidal anti-inflammatory drugs (NSAIDs) are related to dose and release form; however, there is little US evidence. This study assessed the relationships between diclofenac dose and release form on gastrointestinal (GI), cardiovascular (CV), and renal events using US health care claims.

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