• Article

On the resolution of fenfluramine

Resolution of fenfluramine with (+)-dibenzoyltartaric acid affords (+)-fenfluramine in contradiction of literature claims that (-)-fenfluramine is obtained by use of (+)-dibenzoyltartaric acid. The intermediate dibenzoyltartrate salt has been fully characterized and the absolute configuration of the enantiomers of fenfluramine has been confirmed to be as previously established. Use of (-)-dibenzoyltartaric acid, followed by use of (+)-dibenzoyltartaric acid is the preferred method for obtaining both fenfluramine enantiomers


Morehead, A., Reges, R., Lewin, A., & Carroll, F. (1996). On the resolution of fenfluramine. Enantiomer, 1(1), 63-68.