A prospective cohort study using electronic medical records was undertaken to estimate the relative risk (RR) of irritable bowel syndrome (IBS) following acute gastroenteritis (GE) in primary-care patients in The Netherlands and explore risk factors. Patients aged 18-70 years who consulted for GE symptoms from 1998 to 2009, met inclusion/exclusion criteria and had at least 1 year of follow-up data were included. Patients with non-GE consultations, matched by age, gender, consulting practice and time of visit, served as the reference group. At 1 year, 1 center dot 2% of GE patients (N=2428) had been diagnosed with IBS compared to 0 center dot 3% of the reference group (N=2354). GE patients had increased risk of IBS [RR 4 center dot 85, 95% confidence interval (CI) 2 center dot 02-11 center dot 63]. For GE patients, concomitant cramps and history of psycho-social consultations were significantly associated with increased risk. GE patients had increased risk of IBS up to 5 years post-exposure (RR 5 center dot 40, 95% CI 2 center dot 60-11 center dot 24), suggesting there may be other contributing factors.
Relative risk of irritable bowel syndrome following acute gastroenteritis and associated risk factors
Kowalcyk, B., Smeets, HM., Succop, PA., de Wit, NJ., & Havelaar, AH. (2014). Relative risk of irritable bowel syndrome following acute gastroenteritis and associated risk factors. Epidemiology and Infection, 142(6), 1259-1268. https://doi.org/10.1017/s0950268813001891