Reductive ligation mediated one-step disulfide formation of S-nitrosothiols

Zhang, J., Li, S., Zhang, D., Wang, H., Whorton, A. R., & Xian, M. (2010). Reductive ligation mediated one-step disulfide formation of S-nitrosothiols. Organic Letters, 12(18), 4208-4211. https://doi.org/10.1021/ol101863s

Abstract

A one-step reductive ligation mediated disulfide formation of S-nitrosothiols was developed. This reaction involves the reaction of the S-nitroso group with phosphine-thioesters to form sulfenamide and thiolate intermediates, which then undergo a fast intermolecular disulfide formation to form stable conjugates. This reaction can be used to design new biosensors of S-nitrosated proteins.

Publications Info

To contact an RTI author, request a report, or for additional information about publications by our experts, send us your request.

Recent Publications

Article

Protection of forest ecosystems in the eastern United States from elevated atmospheric deposition of sulfur and nitrogen
Article

The use of patient experience feedback in rehabilitation quality improvement and codesign activities
Article

SPTSSA variants alter sphingolipid synthesis and cause a complex hereditary spastic paraplegia
OCCASIONAL PAPER

Bringing an equity-centered framework to research