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Recurrence rates for pediatric benign ovarian neoplasms
Knaus, M. E., Onwuka, A. J., Abouelseoud, N. M., Bergus, K. C., Breech, L. L., Brito, K. S., Dekonenko, C., Hertweck, S. P., Hong, H. Y., Menon, S., Merritt, D. F., Schikler, A. G., Senapati, N., Smith, Y. R., Strickland, J. L., Truehart, A. I., Minneci, P. C., & Hewitt, G. D. (2023). Recurrence rates for pediatric benign ovarian neoplasms. Journal of Pediatric and Adolescent Gynecology, 36(2), 160-166. https://doi.org/10.1016/j.jpag.2022.11.006
Study Objective: To examine the recurrence rates of pediatric benign ovarian neoplasms Methods: A retrospective review of females up to 21 years of age who underwent surgery for a benign ovarian neoplasm at 8 pediatric hospitals from January 2010 through December 2016 was conducted. Data include primary operation details, follow-up imaging, and re -operation details.Results: Four hundred and twenty-six females were included in our cohort, with a median age of 15 years at the time of the primary operation. Of the patients, 69% had a mature teratoma, 18% had a serous cystadenoma, and 8% had a mucinous cystadenoma. Two-thirds of patients underwent ovarian-sparing surgery. There were 11 pathologically confirmed recurrences (2.6%) at a median follow-up of 12.8 months. The pathologically confirmed recurrence was 10.5 per 100 person-months at 12 months (SE = 5.7) for mucinous cystadenomas and 0.4 months (SE = 0.4) for mature teratomas ( P = .001). For half of the patients, the pathologically confirmed recurrences occurred by 12.8 months, and for 75%, they occurred by 23.3 months. There were no differences in reoperation or recurrence on the basis of initial procedure (ovary-sparing surgery vs oophorectomy).Conclusion: We measured the pathologically confirmed recurrence rate for pediatric benign ovarian neoplasms in a large cohort. Oophorec-tomy was not protective against recurrence. Mucinous cystadenomas were at a greater risk of pathologically confirmed recurrence.
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