Many proteins frequently undergo structural rearrangement to complete their functions. Ligand entry and binding are often associated with some degree of localized disorder. Indeed, low populations of disordered excited states may help drive such processes. Characterization of these states is vital to understanding the mechanisms of many biological functions.
Protein dynamic studies move to a new time slot
Cavanagh, J., & Venters, RA. (2001). Protein dynamic studies move to a new time slot. Nature Structural and Molecular Biology, 8(11), 912-914.