Despite many potential applications, miniature mass spectrometers have had limited adoption in the field due to the tradeoff between throughput and resolution that limits their performance relative to laboratory instruments. Recently, a solution to this tradeoff has been demonstrated by using spatially coded apertures in magnetic sector mass spectrometers, enabling throughput and signal-to-background improvements of greater than an order of magnitude with no loss of resolution. This paper describes a proof of concept demonstration of a cycloidal coded aperture miniature mass spectrometer (C-CAMMS) demonstrating use of spatially coded apertures in a cycloidal sector mass analyzer for the first time. C-CAMMS also incorporates a miniature carbon nanotube (CNT) field emission electron ionization source and a capacitive transimpedance amplifier (CTIA) ion array detector. Results confirm the cycloidal mass analyzer's compatibility with aperture coding. A > 10x increase in throughput was achieved without loss of resolution compared with a single slit instrument. Several areas where additional improvement can be realized are identified.
Proof of concept coded aperture miniature mass spectrometer using a cycloidal sector mass analyzer, a carbon nanotube (CNT) field emission electron ionization source, and an array detector
Amsden, J. J., Herr, P. J., Landry, D. M. W., Kim, W., Vyas, R., Parker, C. B., Kirley, M. P., Keil, A. D., Gilchrist, K. H., Radauscher, E. J., Hall, S. D., Carlson, J. B., Baldasaro, N., Stokes, D., Di Dona, S. T., Russell, Z. E., Grego, S., Edwards, S. J., Sperline, R. P., ... Glass, J. T. (2018). Proof of concept coded aperture miniature mass spectrometer using a cycloidal sector mass analyzer, a carbon nanotube (CNT) field emission electron ionization source, and an array detector. Journal of the American Society for Mass Spectrometry, 29(2), 360-372. https://doi.org/10.1007/s13361-017-1820-y