RTI uses cookies to offer you the best experience online. By clicking “accept” on this website, you opt in and you agree to the use of cookies. If you would like to know more about how RTI uses cookies and how to manage them please view our Privacy Policy here. You can “opt out” or change your mind by visiting: http://optout.aboutads.info/. Click “accept” to agree.
Preparation of methadone and some congeners labeled with tritium in the aromatic Rings
Kepler, J., Sparacino, C., Howe, C. R., & Austin, R. (1982). Preparation of methadone and some congeners labeled with tritium in the aromatic Rings. Journal of Labelled Compounds and Radiopharmaceuticals, 19(2), 271-282. https://doi.org/10.1002/jlcr.2580190213
[diphenyl‐2,2′‐3H2]Methadone with specific activity of 8‐30 Ci/mmol was prepared by reductive dehalogenation of 6‐dimethylamino‐4, 4‐bis(2‐chlorophenyl)‐3‐heptanone with carrier‐free tritium gas. The labeled congeners (−)‐α‐acetylmethadol, (−)‐α‐acetyl‐N‐normethadol, and (−)‐α‐acetyl‐N,N‐dinormethadol were prepared from (+)‐[diphenyl‐2,2′‐3H2]methadone.
RTI shares its evidence-based research - through peer-reviewed publications and media - to ensure that it is accessible for others to build on, in line with our mission and scientific standards.