Preparation of methadone and some congeners labeled with tritium in the aromatic Rings

[diphenyl‐2,2′‐3H2]Methadone with specific activity of 8‐30 Ci/mmol was prepared by reductive dehalogenation of 6‐dimethylamino‐4, 4‐bis(2‐chlorophenyl)‐3‐heptanone with carrier‐free tritium gas. The labeled congeners (−)‐α‐acetylmethadol, (−)‐α‐acetyl‐N‐normethadol, and (−)‐α‐acetyl‐N,N‐dinormethadol were prepared from (+)‐[diphenyl‐2,2′‐3H2]methadone.

Kepler, J., Sparacino, C., Howe, C. R., & Austin, R. (1982). Preparation of methadone and some congeners labeled with tritium in the aromatic Rings. Journal of Labelled Compounds and Radiopharmaceuticals, 19(2), 271-282. https://doi.org/10.1002/jlcr.2580190213