Potentiation of Francisella Resistance to Conventional Antibiotics through Small Molecule Adjuvants
A screen of 20 compounds identified small molecule adjuvants capable of potentiating anitbiotic activty against Francisella philomiragia. Analogue synthesis of an initial hit compound led to the discovery of a potentially new class of small molecule adjuvants containg an indole core. The lead compound was able to lower the MIC of colistin by 32-fold against intrinsically resistant F. philomiragia.
Stephens, M. D., Hubble, V. B., Ernst, R. K., van Hoek, M. L. M., Cavanagh, J., & Melander C, . U. (2016). Potentiation of Francisella Resistance to Conventional Antibiotics through Small Molecule Adjuvants. MedChemComm, 7(11), 128-131. DOI: 10.1039/C5MD00353A