Plasma nutrient biomarkers are associated with waist-to-height ratio in youth with type 1 diabetes

Archana Pande Lamichhane; Shanshan Wang; Jamie L Crandell; Sarah C Couch; Irena B King; Jean M Lawrence; Dana Dabelea; Archana Pande Lamichhane; Grace Kim; Ronny A Bell; Shankuan Zhu; Elizabeth J Mayer-Davis

Plasma nutrient biomarkers are associated with waist-to-height ratio in youth with type 1 diabetes

Wang, S., Crandell, J. L., Couch, S. C., King, I. B., Lawrence, J. M., Dabelea, D., Lamichhane, A. P., Kim, G., Bell, R. A., Zhu, S., & Mayer-Davis, E. J. (2015). Plasma nutrient biomarkers are associated with waist-to-height ratio in youth with type 1 diabetes. Journal of Nutrition, 145(3), 579-586. https://doi.org/10.3945/jn.114.203133

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Abstract

BACKGROUND: Plasma fatty acids (FAs) and micronutrients have been associated with central obesity in adults; however, previous studies of these associations in adults have yielded mixed results. In addition, no comparable research has been conducted among youth with type 1 diabetes (T1D).

OBJECTIVE: We investigated the cross-sectional and longitudinal associations between plasma nutrient biomarkers and waist-to-height ratio (WHtR) in youth with T1D.

METHODS: These analyses included 1324 youth aged 3-20 y at T1D diagnosis with a baseline visit in the SEARCH (Search for Diabetes in Youth) Study and a subset of 1178 of these youth with a follow-up visit an average of 23 mo (range: 16-40 mo) after their baseline visit. Plasma phospholipid FAs and vitamins were measured, and estimated desaturase activities were calculated at baseline. Anthropometric measurements and diabetes-related assessments were collected at each visit. Multiple linear regression was used to examine the association between plasma nutrient biomarkers and WHtR.

RESULTS: In cross-sectional analysis, plasma palmitic acid (P = 0.004), dihomo-γ-linolenic acid (DGLA; P = 0.017) and Δ6 desaturase (D6D; P = 0.006) were positively correlated with WHtR after adjustment of confounders. Oleic acid (OA; P = 0.002), linoleic acid (LA; P = 0.015), Δ9 desaturase 18 (D9D-18; P = 0.027), and vitamin D (P < 0.0001) were negatively correlated with WHtR after adjustment. Weight status was an effect modifier (P < 0.05). In normal-weight youth, vitamin D (P = 0.003) was negatively associated with WHtR. In obese youth, stearic acid (P = 0.037), DGLA (P < 0.0001), and D6D (P < 0.0001) were positively associated and OA (P = 0.0008), D9D-18 (P = 0.0006), and vitamin D (P < 0.0001) were negatively associated with WHtR. In longitudinal analysis, baseline linoleic acid (P = 0.018), n-6:n-3 (ω-3:ω-6) FA ratio (P = 0.029), vitamin D (P = 0.003), and vitamin E (P < 0.0001) were negatively correlated with WHtR at follow-up only in obese participants.

CONCLUSIONS: In T1D youth, plasma FAs and vitamins are associated with WHtR and are modified by weight status. These associations are particularly marked in obese youth.