• Patent

Pharmaceutical compositions and methods employing camptothecins

Citation

Wall, M., Wani, M., Nicholas, A., & Manikumar, G. (1993). IPC No. U.S.Pharmaceutical compositions and methods employing camptothecins (Patent No. 5227380.)

Abstract

A method for synthesizing camptothecin and camptothecin analogs using a novel hydroxyl-containing tricyclic intermediate and the camptothecin analogs produced by the process. The camptothecin analogs are effective inhibitors of topoisomerase I and show antileukemic and anti-tumor activity.