A method for synthesizing camptothecin and camptothecin analogsusing a novel hydroxyl-containing tricyclic intermediate and thecamptothecin analogs produced by the process. The camptothecinanalogs are effective inhibitors of topoisomerase I and showantileukemic and anti-tumor activity.
Pharmaceutical compositions and methods employing camptothecins
Wall, M., Wani, M., Nicholas, A., & Manikumar, G. (1993). Pharmaceutical compositions and methods employing camptothecins. (U.S. Patent No. 5227380). http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=5227380