Pharmaceutical compositions and methods employing camptothecins
A method for synthesizing camptothecin and camptothecin analogsusing a novel hydroxyl-containing tricyclic intermediate and thecamptothecin analogs produced by the process. The camptothecinanalogs are effective inhibitors of topoisomerase I and showantileukemic and anti-tumor activity.
Wall, M., Wani, M., Nicholas, A., & Manikumar, G. (1993). IPC No. U.S.Pharmaceutical compositions and methods employing camptothecins (Patent No. 5227380.)