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Pharmaceutical compositions and methods employing camptothecins

Wall, M., Wani, M., Nicholas, A., & Manikumar, G. (1993). Pharmaceutical compositions and methods employing camptothecins. (U.S. Patent No. 5227380). http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=5227380

Abstract

A method for synthesizing camptothecin and camptothecin analogs using a novel hydroxyl-containing tricyclic intermediate and the camptothecin analogs produced by the process. The camptothecin analogs are effective inhibitors of topoisomerase I and show antileukemic and anti-tumor activity.

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