One-pot thioether formation from S-nitrosothiols
Zhang, D., Devarie-Baez, N. O., Pan, J., Wang, H., & Xian, M. (2010). One-pot thioether formation from S-nitrosothiols. Organic Letters, 12(24), 5674-5676. https://doi.org/10.1021/ol102491n
Abstract
Protein S-nitrosation is an important post-translational modification. However, the detection of S-nitrosation is still problematic because S-nitrosation products, that is, S-nitrosothiols, are unstable species. Here a new reaction which can selectively convert unstable S-nitrosothiols to stable thioethers in one-pot under very mild conditions is reported. This reaction has the potential to be applied in the detection of protein S-nitrosation.
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