Oleanolic acid, a bioactive component of the leaves of ocimum gratissimum (lamiaceae)
Njoku, C. J., Zeng, L., Asuzu, I. U., Oberlies, N., & McLaughlin, J. L. (1997). Oleanolic acid, a bioactive component of the leaves of ocimum gratissimum (lamiaceae). International Journal of Pharmacognosy, 35(2), 134-137. DOI: 10.1076/phbi.126.96.36.19990
Bioactivity-guided fractionation of the leaves of Ocimum gratissimum L. (Lamiaceae), using the brine shrimp lethality test, led to the isolation of oleanolic acid. Oleanolic acid showed bioactivity against a panel of six human solid tumor cell lines, the nematode Caenorhabditis elegans and yellow fever mosquito larvae Aedes aegypti . Details of the isolation and bioactivities are described.