A new prenylated flavonol from the root of Petalostemon purpureus

Huang, L., Fullas, F., McGivney, R., Brown, D., Wani, M., Wall, M., Tucker, JC., Beecher, CW., Pezzuto, JM., & Kinghorn, AD. (1996). A new prenylated flavonol from the root of Petalostemon purpureus. Journal of Natural Products, 59(3), 290-292.

Abstract

A new prenylated flavonol, petalopurpurenol (1), and a known dihydroflavonol, petalostemumol (2), have been isolated by DNA scission-guided fractionation of the organic portion of a 20% MeOH/CHCl3/H2O partition of a 50% MeOH/CHCl3 extract of the roots of Petalostemon purpureus. Compound 2 displayed moderate activity in DNA-scission assay. Both compounds 1 and 2 were evaluated for cytotoxicity in a panel of human cancer cell lines. The structures of petalopurpurenol (1) and petalostemumol (2) were determined by spectroscopic analysis

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