New compounds with DNA strand-scission activity from the combined leaf and stem of Uvaria hamiltonii
Two flavanones, hamiltones A (1) and B (2), an aurone, hamiltrone (3), a chalcone, hamilcone (4), and a tetrahydroxanthene, hamilxanthene (5), were isolated from Uvaria hamiltonii extracts guided initially by fractionation based on DNA strand-scission and/or 9KB cytotoxicity assays. Compounds 2?5 have not been reported previously, while 1 is new as a natural product. Structural assignments were made based on extensive spectroscopic measurements. Compounds 1?3 were inactive in the 9KB cytotoxicity assay, with compounds 4 and 5 having weak activity. In the DNA strand-scission assay, 3 was the most active compound found in the DNA strand-scission assay, being 10 times more potent than 1 or 2. Compound 4 was only weakly active, and 5 was inactive.
Huang, L., Wall, M., Wani, M., Navarro, H., Santisuk, T., Reutrakul, V., ... Kinghorn, A. D. (1998). New compounds with DNA strand-scission activity from the combined leaf and stem of Uvaria hamiltonii. Journal of Natural Products, 61(4), 446-450. DOI: 10.1021/np9703609