Three new biphenyl derivatives, clusiparalicolines A (1), B (2), and C (3), were isolated from the roots of Clusia paralicola by bioassay-directed fractionation using the DNA strand-scission and the KB human cancer cell line cytotoxicity assays. Compounds 1 and 2 were found to be active in the DNA strand-scission assay, whereas all three compounds exhibited modest cytotoxicity against the KB cell line. The structures of 1?3 were elucidated by spectroscopic methods including 1D and 2D NMR techniques.
New biphenyl compounds with DNA strand-scission activity from Clusia paralicola
Seo, E-K., Huang, L., Wall, M., Wani, M., Navarro, H., Mukherjee, R., Farnsworth, NR., & Kinghorn, AD. (1999). New biphenyl compounds with DNA strand-scission activity from Clusia paralicola. Journal of Natural Products, 62(11), 1484-1487. https://doi.org/10.1021/np980509w