Modified vaccinia ankara virus vaccination provides long-term protection against nasal rabbitpox virus challenge

Jones, D. I., McGee, C. E., Sample, C. J., Sempowski, G. D., Pickup, D. J., & Staats, H. F. (2016). Modified vaccinia ankara virus vaccination provides long-term protection against nasal rabbitpox virus challenge. Clinical and Vaccine Immunology, 23(7), 648-651. https://doi.org/10.1128/CVI.00216-16

Abstract

Modified vaccinia Ankara virus (MVA) is a smallpox vaccine candidate. This study was performed to determine if MVA vaccination provides long-term protection against rabbitpox virus (RPXV) challenge, an animal model of smallpox. Two doses of MVA provided 100% protection against a lethal intranasal RPXV challenge administered 9 months after vaccination.

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