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Methods of treating colon tumors with tumor-inhibiting camptothecin compounds

Giovannella, BC., Liu, LF., Potmesil, M., Wall, MC., Silber, RF., & Wani, M. (1993). Methods of treating colon tumors with tumor-inhibiting camptothecin compounds. (U.S. Patent No. 5225404). http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=5225404

Abstract

The present invention provides methods of treating malignant colon and colo-rectal cancer in mammals, by reducing or inhibiting or retarding such colon cancer tumors in mammals. These methods employ the administration of a tumor-inhibiting or reducing camptothecin compound, e.g., 9-amino-20(RS)-camptothecin, 10,11-methylenedioxy-20(RS)-camptothecin, and the sodium salt of 10,11-methylenedioxy-20(RS)-camptothecin, or a combination thereof. Also provided are pharmaceutical formulations.

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