Methods of treating colon tumors with tumor-inhibiting camptothecin compounds
The present invention provides methods of treating malignantcolon and colo-rectal cancer in mammals, by reducing or inhibitingor retarding such colon cancer tumors in mammals. These methodsemploy the administration of a tumor-inhibiting or reducingcamptothecin compound, e.g., 9-amino-20(RS)-camptothecin,10,11-methylenedioxy-20(RS)-camptothecin, and the sodium salt of10,11-methylenedioxy-20(RS)-camptothecin, or a combination thereof.Also provided are pharmaceutical formulations.
Giovannella, B. C., Liu, L. F., Potmesil, M., Wall, M. C., Silber, R. F., & Wani, M. (1993). IPC No. U.S.Methods of treating colon tumors with tumor-inhibiting camptothecin compounds (Patent No. 5225404.)