Melatonin and agomelatine for preventing seasonal affective disorder
Kaminski-Hartenthaler, A., Nussbaumer, B., Forneris, C. A., Morgan, L., Gaynes, B. N., Sonis, J. H., ... Gartlehner, G. (2015). Melatonin and agomelatine for preventing seasonal affective disorder. Cochrane Database of Systematic Reviews, 11, CD0211271. DOI: 10.1002/14651858.CD011271.pub2
No available methodologically sound evidence indicates that melatonin or agomelatine is or is not an effective intervention for prevention of SAD and improvement of patient-centred outcomes among adults with a history of SAD. Lack of evidence clearly shows the need for well-conducted, controlled studies on this topic. A well-conducted RCT of melatonin or agomelatine for prevention of SAD would assess the comparative benefits and risks of these interventions against others currently used to treat the disorder.