A new cinnamylphenol, macharistol (1), along with a known pterocarpan, (+)-medicarpin (2), were isolated as cytotoxic constituents from the stems of Machaerium aristulatum. In addition, a known pterocarpan, (+)-maackiain (3), and a known isoflavone, formononetin (4), were identified as inactive constituents. Compound 1 was evaluated in the in vivo hollow fiber assay with KB, Col-2, and hTERT-RPE1 cells and found to be inactive at the highest dose (25 mg/kg body weight) tested.
Macharistol, a new cytotoxic cinnamylphenol from the stems of Machaerium aristulatum
Seo, E-K., Kim, NC., Mi, QW., Chai, HY., Wall, M., Wani, M., Navarro, H., Burgess, J., Graham, JG., Cabieses, F., Tan, GT., Farnsworth, NR., Pezzuto, JM., & Kinghorn, AD. (2001). Macharistol, a new cytotoxic cinnamylphenol from the stems of Machaerium aristulatum. Journal of Natural Products, 64(11), 1483-1485. https://doi.org/10.1021/np0103158