• Journal Article

Macharistol, a new cytotoxic cinnamylphenol from the stems of Machaerium aristulatum

Citation

Seo, E-K., Kim, N. C., Mi, Q. W., Chai, H. Y., Wall, M., Wani, M., ... Kinghorn, A. D. (2001). Macharistol, a new cytotoxic cinnamylphenol from the stems of Machaerium aristulatum. Journal of Natural Products, 64(11), 1483-1485. DOI: 10.1021/np0103158

Abstract

A new cinnamylphenol, macharistol (1), along with a known pterocarpan, (+)-medicarpin (2), were isolated as cytotoxic constituents from the stems of Machaerium aristulatum. In addition, a known pterocarpan, (+)-maackiain (3), and a known isoflavone, formononetin (4), were identified as inactive constituents. Compound 1 was evaluated in the in vivo hollow fiber assay with KB, Col-2, and hTERT-RPE1 cells and found to be inactive at the highest dose (25 mg/kg body weight) tested.