Localization of G-protein-coupled receptors in health and disease
Edwards, S. W., Tan, C. M., & Limbird, L. E. (2000). Localization of G-protein-coupled receptors in health and disease. Trends in Pharmacological Sciences, 21(8), 304-308.
G-protein-coupled receptors (GPCRs) represent a superfamily of proteins, characterized by seven transmembrane alpha-helices, that signal through interactions with a family of heterotrimeric GTP-binding proteins, referred to as G proteins. The broad range of physiological functions associated with GPCRs indicates that a better understanding of these receptors and their regulation can provide a solid foundation for novel pharmacological interventions in a variety of disease states.