Lamotrigine and the risk of malformations in pregnancy
Cunnington, M. L., & Tennis, P. (2005). Lamotrigine and the risk of malformations in pregnancy. Neurology, 64, 955-960.
Objective: To report the frequency of major malformations in lamotrigine-exposed pregnancies from September1, 1992, through March 31, 2004, in the International Lamotrigine Pregnancy Registry.
Methods: Health care professionals throughout the world can voluntarily enroll lamotrigine-exposed pregnancies in this observational study. Only pregnancies with unknown outcomes at the time of enrollment were included in the analysis. The percentage of outcomes with major birth defects was calculated as the total number of outcomes with major birth defects divided by the sum of thenumber of outcomes with major birth defects the number of live births without defects.
Results: Among 414 first-trimester exposures to lamotrigine monotherapy, 12 outcomes with major birth defects were reported (2.9%, 95% CI 1.6%to 5.1%). Among the 88 first-trimester exposures to lamotrigine polytherapy including valproate, 11 outcomes with major birth defects were reported (12.5%; 95% CI 6.7% to 21.7%). Among 182 first-trimester exposures to lamotrigine polytherapy excluding valproate, 5 outcomes with major birth defects were reported (2.7%, 95% CI 1.0% to 6.6%). Nodistinctive pattern of major birth defects was apparent among the offspring exposed to lamotrigine monotherapy or polytherapy.
Conclusions: The risk of all major birth defects after first-trimester exposure to lamotrigine monotherapy(2.9%) was similar to that in the general population and in other registries enrolling women exposed to antiepileptic monotherapy (3.3% to 4.5%). However, the sample size was too small to detect any but very large increases in specific birth defects.