Compounds of the formula ##STR1## wherein R.sub.1 isCH.dbd.CY--C(CH.sub.3).dbd.CHX wherein X and Y are different andeach is of the formula ##STR2## wherein R' and R" independently areH or alkyl of C.sub.1-6 and R.sub.1 includes all possible geometricisomers are demonstrated effective in treating inflammation, bothtopically and internally. The mechanism appears to be theinhibition of phospholipase A.sub.2 enzymes.
Isoprenoid phospholipase A2 inhibitors and preparations comprising same
Carroll, F., Lewin, A., Tramposch, K., & Steiner, SA. (1992). IPC No. U.S. Isoprenoid phospholipase A2 inhibitors and preparations comprising same. (U.S. Patent No. 5141959).