Isoprenoid phospholipase A2 inhibitors and preparations comprising same
Carroll, F., Lewin, A., Tramposch, K., & Steiner, S. A. (1992). IPC No. U.S.Isoprenoid phospholipase A2 inhibitors and preparations comprising same (Patent No. 5141959.)
Compounds of the formula ##STR1## wherein R.sub.1 isCH.dbd.CY--C(CH.sub.3).dbd.CHX wherein X and Y are different andeach is of the formula ##STR2## wherein R' and R" independently areH or alkyl of C.sub.1-6 and R.sub.1 includes all possible geometricisomers are demonstrated effective in treating inflammation, bothtopically and internally. The mechanism appears to be theinhibition of phospholipase A.sub.2 enzymes.