Isoprenoid phospholipase A2 inhibitors and preparations comprising same
Carroll, F., Lewin, A., Tramposch, K., & Steiner, SA. (1992). Isoprenoid phospholipase A2 inhibitors and preparations comprising same. (U.S. Patent No. 5141959). http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=5141959
Compounds of the formula ##STR1## wherein R.sub.1 is CH.dbd.CY--C(CH.sub.3).dbd.CHX wherein X and Y are different and each is of the formula ##STR2## wherein R' and R" independently are H or alkyl of C.sub.1-6 and R.sub.1 includes all possible geometric isomers are demonstrated effective in treating inflammation, both topically and internally. The mechanism appears to be the inhibition of phospholipase A.sub.2 enzymes.