Inhibition of respiratory syncytial virus-induced cell fusion by amidino compounds
Tidwell, R. R., Dubovi, E. J., & Geratz, J. D. (1983). IPC No. U.S.Inhibition of respiratory syncytial virus-induced cell fusion by amidino compounds (Patent No. 4397863.)
A number of aromatic mono- and bis-amidines are capable ofblocking cell fusion induced by Respiratory Syncytial (RS) virus.Suitable amidino compounds include those selected from the groupconsisting of 1-4-di(4-amidinophenoxy)-2-butanol;bis(5-amidino-2-benzimidazolyl)methane;1,2-bis(5-amidino-2-benzimidazolyl )ethane; 5-amidino-indole;5-amidinobenzimidazole, 5-amidino-1-methylindole and5-amidino-1-(4-amidinobenzyl)indole. The most powerful of thecompounds, bis(5-amidino-2-benzimidazolyl)methane (BABIM), is ableto achieve complete suppression of syncytium formation at aconcentration of 1 .mu.M. Inhibition occurs in RS virus-infectedHep-2 cells as well as CV-1 cells. BABIM also causes a significantretardation of RS virus penetration, but does not interfere withadsorption. Addition of the amidines after the penetration of RSvirus does not affect single cycle yields. The compounds may beused in the prophylactic control of RS virus in man.