Increased risk of acute hepatitis B among adults with diagnosed diabetes mellitus
Reilly, M. L., Schillie, S. F., Smith, E., Poissant, T., Vonderwahl, C. W., Gerard, C., ... Murphy, T. V. (2012). Increased risk of acute hepatitis B among adults with diagnosed diabetes mellitus. Journal of diabetes science and technology, 6(4), 858-866.
The risk of acute hepatitis B among adults with diabetes mellitus is unknown. We investigated the association between diagnosed diabetes and acute hepatitis B.
Confirmed acute hepatitis B cases were reported in 2009–2010 to eight Emerging Infections Program (EIP) sites; diagnosed diabetes status was determined. Behavioral Risk Factor Surveillance System respondents residing in EIP sites comprised the comparison group. Odds ratios (ORs) comparing acute hepatitis B among adults with diagnosed diabetes versus without diagnosed diabetes were determined by multivariate logistic regression, adjusting for age, sex, and race/ethnicity, and stratified by the presence or absence of risk behaviors for
hepatitis B virus (HBV) infection.
During 2009–2010, EIP sites reported 865 eligible acute hepatitis B cases among persons aged ?23 years; 95 (11.0%) had diagnosed diabetes. Comparison group diabetes prevalence was 9.1%. Among adults without hepatitis B risk behaviors and with reported diabetes status, the OR for acute hepatitis B comparing adults
with and without diabetes was 1.9 (95% confidence interval [CI] = 1.4, 2.6); ORs for adults ages 23–59 and ?60 years were 2.1 (95% CI = 1.6, 2.8) and 1.5 (95% = CI 0.9, 2.5), respectively.
Diabetes was independently associated with an increased risk for acute hepatitis B among adults without HBV risk behaviors.