Immune perturbations in HIV-1-infected individuals who make broadly neutralizing antibodies
Induction of broadly neutralizing antibodies (bnAbs) is a goal of HIV-1 vaccine development. bnAbs occur in some HIV-1-infected individuals and frequently have characteristics of autoantibodies. We have studied cohorts of HIV-1-infected individuals who made bnAbs and compared them with those who did not do so, and determined immune traits associated with the ability to produce bnAbs. HIV-1-infected individuals with bnAbs had a higher frequency of blood autoantibodies, a lower frequency of regulatory CD4+ T cells, a higher frequency of circulating memory T follicular helper CD4+ cells, and a higher T regulatory cell level of programmed cell death-1 expression compared with HIV-1-infected individuals without bnAbs. Thus, induction of HIV-1 bnAbs may require vaccination regimens that transiently mimic immunologic perturbations in HIV-1-infected individuals.
Moody, M. A., Pedroza-Pacheco, I., Vandergrift, N. A., Chui, C., Lloyd, K. E., Parks, R., ... Haynes, B. F. (2016). Immune perturbations in HIV-1-infected individuals who make broadly neutralizing antibodies. Science Immunology, 1(1), [aag0851]. DOI: 10.1126/sciimmunol.aag0851