• Journal Article

High-valent intermediates of heme proteins and model compounds

Citation

Harris, D. (2001). High-valent intermediates of heme proteins and model compounds. Current Opinion in Chemical Biology, 5(6), 724-735. DOI: 10.1016/S1367-5931(01)00272-1

Abstract

Recent computational and experimental probes of high-valent intermediates in heme proteins and model compounds reveal a rich spectrum of chemical behavior that is dependent on the nature of the proximal ligand, metal center, distal- and proximal-binding site environment, porphyrin macrocycle architecture, and consequent electronic structure. The results of such studies reveal an underlying complexity, which is simply understood once one is cognizant of the 'chameleon'-like behavior of such intermediates is determined by the high-valent intermediate environment