Thank you for the opportunity to respond to Michael Honeycutt's letter to the editor. We provided a calculation in the discussion of our publication to put the ingested doses of hexavalent chromium (Cr(VI)) in mice during the National Toxicological Program's 2-year bioassay into context with potential human exposure. This information was a minor component of the publication and was not presented in the context of a human risk assessment. As with any calculation, certain assumptions were made as outlined in the paper. Specifically, we calculated a time-weighted average daily dose of Cr(VI) for the entire 2-year mouse study based on water consumption and body weight data recorded over the course of the study and determined the equivalent human daily dose. We then compared the human equivalent daily dose to the doses estimated to result from exposure to the highest concentrations in water reported for...
