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Gummiferol, a cytotoxic polyacetylene from the leaves of Adenia gummifera

Fullas, F., Brown, D., Wani, M., Wall, M., Chagwedera, TE., Farnsworth, NR., Pezzuto, JM., & Kinghorn, AD. (1995). Gummiferol, a cytotoxic polyacetylene from the leaves of Adenia gummifera. Journal of Natural Products, 58(10), 1625-1628.

Abstract

A new polyacetylenic diepoxide compound, gummiferol [1] was isolated from the leaves of Adenia gummifera by KB cytotoxicity-guided fractionation. Compound 1 exhibited significant activity against the KB human cell line and a broad cytotoxic spectrum against other human cancer cell lines. The structure of 1 was established primarily on the basis of its spectral data

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