Obesity and asthma are two significant public health issues worldwide. Accumulating evidence has related high body mass index (BMI) and obesity with asthma (1), although a causal role of obesity in the development of asthma remains uncertain. A recent study reported a significant association between genetic predisposition to obesity, estimated by a genetic risk score (GRS) based on 32 BMI-associated variants, and increased risk of childhood asthma in 4,835 European children, supporting a potential causal relationship between obesity and asthma (2). However, it remains unknown whether genetic predisposition to obesity is associated with later-onset asthma which is different from childhood-onset asthma (3). This article is protected by copyright. All rights reserved.
