Obesity and asthma are two significant public health issues worldwide. Accumulating evidence has related high body mass index (BMI) and obesity with asthma (1), although a causal role of obesity in the development of asthma remains uncertain. A recent study reported a significant association between genetic predisposition to obesity, estimated by a genetic risk score (GRS) based on 32 BMI-associated variants, and increased risk of childhood asthma in 4,835 European children, supporting a potential causal relationship between obesity and asthma (2). However, it remains unknown whether genetic predisposition to obesity is associated with later-onset asthma which is different from childhood-onset asthma (3). This article is protected by copyright. All rights reserved.
Genetic predisposition to obesity is associated with asthma in US Hispanics/Latinos
Results from the Hispanic community health study/study of Latinos
Guo, Y., Moon, J-Y., Laurie, C. C., North, K. E., Sanchez-Johnsen, L. A., Davis, S., Yu, B., Nyenhuis, S. M., Kaplan, R., Rastogi, D., & Qi, Q. (2018). Genetic predisposition to obesity is associated with asthma in US Hispanics/Latinos: Results from the Hispanic community health study/study of Latinos. Allergy, 73(7), 1547-1550. https://doi.org/10.1111/all.13450