• Journal Article

Genetic and immunological host factors associated with susceptibility to HIV-1 infection

Citation

Buchacz, K. A., Wilkinson, D. A., Krowka, J. F., Koup, R. A., & Padian, N. (1998). Genetic and immunological host factors associated with susceptibility to HIV-1 infection. AIDS, 12 Suppl A:S87-94., S87-S94.

Abstract

The probability of HIV transmission depends on the interplay of many different factors related to infectiousness of the HIV-infected partner, susceptibility of the HIV-uninfected partner, and biological characteristics of HIV strains. Here, we review recent studies of host immunological and genetic factors which may affect susceptibility to HIV-1 infection. These factors are summarized in Table 1. We propose how to explore biological correlates of susceptibility to HIV-1 infection in epidemiological studies, discuss the strengths and limitations of this research, and address the implications for public health