Exploring the Scope for Scale-Up of Organic Chemistry Using a Large Batch Microwave Reactor
Schmink, J. R., Kormos, C. M., Devine, W. G., & Leadbeater, N. E. (2010). Exploring the Scope for Scale-Up of Organic Chemistry Using a Large Batch Microwave Reactor. Organic Process Research and Development, 14(1), 205-214. DOI: 10.1021/op900287j
A new batch microwave reactor has been evaluated in the context of palladium-mediated transformations, condensation reactions, nucleophilic aromatic substitution reactions, and alkylations. Importantly, a linear scaling approach was taken, no changes being made to the protocol when moving from the small, developmental scale to larger scales. In some cases reactions were scaled over 18,000-fold when moving from small (0.1-1 nmol) to large (1-18 mol) runs.