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Evaluation of retinoids as therapeutic agents in dermatology

Lewin, A., Bos, ME., Zusi, FC., Nair, X., Whiting, G., Bouquin, P., Tetrault, G., & Carroll, F. (1994). Evaluation of retinoids as therapeutic agents in dermatology. Pharmaceutical Research, 11(2), 192-200.

Abstract

Evaluation of 13-cis-12-substituted analogues of retinoic acid in a series of dermatologic screens has revealed that structural modifications can lead to selectivity and specificity. An analogue, 11-cis,13-cis-12-hydroxymethylretinoic acid, delta-lactone, has been found to have good activity and to be devoid of topical and systemic toxicity

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