Evaluation of 13-cis-12-substituted analogues of retinoic acid in a series of dermatologic screens has revealed that structural modifications can lead to selectivity and specificity. An analogue, 11-cis,13-cis-12-hydroxymethylretinoic acid, delta-lactone, has been found to have good activity and to be devoid of topical and systemic toxicity
Evaluation of retinoids as therapeutic agents in dermatology
Lewin, A., Bos, ME., Zusi, FC., Nair, X., Whiting, G., Bouquin, P., Tetrault, G., & Carroll, F. (1994). Evaluation of retinoids as therapeutic agents in dermatology. Pharmaceutical Research, 11(2), 192-200.