More than 200 asthma candidate genes have been examined in human association studies or identified with knockout mouse approaches. However, many have not been systematically replicated in human populations, especially those containing a large number of tagging single nucleotide polymorphisms (SNPs).
Evaluation of candidate genes in a genome-wide association study of childhood asthma in Mexicans
Wu, H., Romieu, I., Shi, M., Hancock, D. B., Li, H., Sienra-Monge, J-J., Chiu, G. Y., Estela del Rio-Navarro, B., & London, S. J. (2010). Evaluation of candidate genes in a genome-wide association study of childhood asthma in Mexicans. Journal of Allergy and Clinical Immunology, 12(7), 321-327. https://doi.org/10.1016/j.jaci.2009.09.007