• Journal Article

Effect of a non-hygroscopic surfactant coating upon fluorescein absorption from the respiratory tract

Citation

Hickey, A., & Byron, P. R. (1987). Effect of a non-hygroscopic surfactant coating upon fluorescein absorption from the respiratory tract. Drug Design and Discovery, 2(1), 35-39.

Abstract

The influence of a hydrophobic coating upon the absorption of fluorescein from the canine respiratory tract has been evaluated. Lauric acid was adsorbed onto the surface of micronized disodium fluorescein powder suspended in non-aqueous solutions of the fatty acid. A 0.24 g lauric acid coating for each gram of dye was sufficient to prevent hygroscopic growth in a 40 sec period at 37 C at 97% relative humidity. When this powder was aerosolized and administered by inhalation to Beagle dogs, fluorescein absorption proceeded at similar rates to that of the uncoated dye