Effect of high-dose fluconazole on QT interval in patients with human immunodeficiency virus (HIV)-associated cryptococcal meningitis
Azoles may cause prolongation of the QT interval either directly or by inhibiting the hepatic metabolism of other QT-prolonging agents  S. Wassmann, G. Nickenig and M. Böhm, Long QT syndrome and torsade de pointes in a patient receiving fluconazole, Ann Intern Med 131 (1999), p. 797. View Record in Scopus | Cited By in Scopus (33) and . Ketoconazole is known to block the human ether-a-go-go-related gene (hERG) product and thereby inhibit the potassium IKr current in the heart . Whether fluconazole also inhibits hERG is currently unknown.