Environmental endotoxin and alum-adjuvanted vaccines did not influence peanut-allergy development in mice. Exposure to alum and CpG-adjuvanted vaccines indirectly reduced allergic disease severity. Fecal metabolites differentiated mice based on disease severity.
Effect of endotoxin and alum adjuvant vaccine on peanut allergy
Johnson-Weaver, B. T., McRitchie, S., Mercier, K. A., Pathmasiri, W., Sumner, S. J., Chan, C., Germolec, D., Kulis, M., Burks, A. W., & Staats, H. F. (2018). Effect of endotoxin and alum adjuvant vaccine on peanut allergy. Journal of Allergy and Clinical Immunology, 141(2), 791-794. https://doi.org/10.1016/j.jaci.2017.07.043