Effect of endotoxin and alum adjuvant vaccine on peanut allergy
Johnson-Weaver, B. T., McRitchie, S., Mercier, K. A., Pathmasiri, W., Sumner, S. J., Chan, C., ... Staats, H. F. (2017). Effect of endotoxin and alum adjuvant vaccine on peanut allergy. Journal of Allergy and Clinical Immunology. DOI: 10.1016/j.jaci.2017.07.043
Environmental endotoxin and alum-adjuvanted vaccines did not influence peanut-allergy development in mice. Exposure to alum and CpG-adjuvanted vaccines indirectly reduced allergic disease severity. Fecal metabolites differentiated mice based on disease severity.